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This site is intended for patients in the UK who have been prescribed Entresto® (sacubitril/valsartan). This website has been developed and funded by Novartis Pharmaceuticals UK Ltd. If you are a member of the public, please click here

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Heart failure and its impact

You have been prescribed Entresto® (sacubitril/valsartan) because you have been diagnosed with symptomatic chronic heart failure with reduced ejection fraction.1 Heart Failure is a condition where your heart can't pump blood around your body as well as it should. It doesn't mean your heart has stopped working but you may need support to help it work better.2 This is the aim of your Entresto® treatment.

About sacubitril/valsartan and why it has been prescribed

Entresto is a heart medicine containing an angiotensin receptor neprilysin inhibitor. It delivers two active substances, sacubitril and valsartan. The aim of this medicine is to combat the main symptoms of heart failure by relaxing the blood vessels and improving your heart’s ejection fraction, therefore allowing it to pump more efficiently.3,4

Sacubitril/valsartan is prescribed for adult patients for treatment of symptomatic chronic heart failure with reduced ejection fraction.

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YOURCHOICE
ENGAGE

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Supporting you at every stage of your treatment journey

The Entresto® YOURCHOICE ENGAGE programme provides patients like you with valuable support on your treatment journey. Through regular emails we can support you in learning more about your Entresto® treatment, understand how to manage any possible side effects and even help you to find further helpful information and resources.

YOURCHOICE ENGAGE can also help you to:

  • Find reliable and up-to-date information relevant to you

  • Read and hear stories from other patients

  • Learn tips to help you stay on track with your treatment

  • Discover information and sources of emotional and well-being support

Please read the following information which will help 
you get the most out of your treatment:

1| Keep up with your medication

It is important that you keep taking this medicine even if you think you are feeling better. Do not stop taking your medicine unless your doctor tells you to.

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2| Stick to a schedule

It is advisable to take this medicine at the same time everyday. If you forget, you should simply take the next one at the next scheduled time. Do not take a double dose to make up for the dose you forgot to take.

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3| What are the side effects?

The most common side effects that you may develop are low blood pressure (dizziness, light-headedness), a high level of potassium in the blood (which would be detected when your doctor performed a blood test) or decreased kidney function.

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4| Do not hesitate to ask

If you experience anything that worries you, please talk to your heart failure doctor, nurse or pharmacist as soon as possible. They will be able to give you additional advice.

Understanding treatment

Visit our ‘Understanding treatment’ page to learn why you have been prescribed sacubitril/valsartan, what the treatment aims to do and the side effects associated with it, so you know what to expect.

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Understanding heart failure

Learn about the causes of heart failure, the symptoms associated with it and read our tips on how to live with it.

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How sacubitril/valsartan works

Watch our mode of action video to understand Entresto's effect on the heart.

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Keep on track

Ensure you never miss a dose again by downloading the Medisafe Pill reminder mobile app. You will receive regular notifications that remind you to take your medication. Novartis has no control over the content of the MediSafe app.

References

  1. Entresto 24 mg/26 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: https://www.medicines.org.uk/emc/product/7751/smpc#about-medicine. [Last accessed: July 2024]
  2. Heart Failure. Available online at: https://www.bhf.org.uk/informationsupport/conditions/heart-failure [Last accessed: July 2024]
  3. EMC. Entresto patient information leaflet. Available from: https://www.medicines.org.uk/emc/files/pil.7751.pdf [Last accessed: July 2024]
  4. Does Entresto improve ejection fraction? Available online at: https://www.drugs.com/medical-answers/entresto-improve-ejection-fraction-3538357/#:~:text=Key%20Points-,Entresto%20has%20been%20shown%20to%20increase%20left%20ventricular%20ejection%20fraction,and%20oxygen%20to%20your%20body [Last accessed: July 2024] 

UK | July 2024 | 172742-3