Understanding heart failure

How well do you understand heart failure?

It’s common for people who have been diagnosed with the condition to still feel unsure of what heart failure is and what it could mean.

Heart failure is a condition where your heart can’t pump blood around your body as well as it should. It
doesn’t mean your heart has stopped working but you may need support to help it work better.¹

It can occur at any age but is most common in older people. It is a long-term condition that tends to gradually get worse over time and while it cannot usually be cured, the symptoms can often be controlled for many years.²

Symptoms of heart failure and progression

Entresto^® (sacubitril/valsartan) is designed to alleviate or reduce the symptoms associated with heart failure. When your heart isn’t pumping as well as it should, you might notice some of these symptoms.

Weight Gain

Breathlessness (e.g. While walking)

Tiredness

Swollen legs and ankles

Difficulty with day-to-day activities

Breathless while lying down

Continuous cough

Bloated stomach

For many people the symptoms of heart failure develop slowly over time. It’s really important to understand and monitor your symptoms, so that if you feel different or worse, you can speak to your healthcare professional for advice.

For a select list of symptoms please refer to NHS heart failure symptoms at: https://www.nhs.uk/conditions/heart-failure/symptoms/ for further information.

Ask your family, carer or a friend to help you monitor your symptoms.

Never stop taking your medication without first consulting your healthcare professional

When taking Entresto^®, you may well experience side effects for example light-headedness and dizziness, which could make you feel as though the treatment is not good for you. Stopping your Entresto treatment may cause your heart condition to get worse. You should seek medical advice before you make the decision to stop taking it, even if you are feeling better.

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Supporting you at every stage of your treatment journey

The Entresto^®YOURCHOICE ENGAGE programme provides patients like you with valuable support on your treatment journey. Through regular emails we can support you in learning more about your Entresto^® treatment, understand how to manage any possible side effects and even help you to find further helpful information and resources.

YOURCHOICE ENGAGE can also help you to:

Find reliable and up-to-date information relevant to you
Read and hear stories from other patients
Learn tips to help you stay on track with your treatment
Discover information and sources of emotional and well-being support

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The New York Heart Association (NYHA) Functional Classification

Doctors usually classify patients’ heart failure according to the severity of their symptoms. This table describes the most commonly used classification system, the New York Heart Association (NYHA) Functional Classification³. It places patients in one of four categories based on how much they are limited during physical activity.⁴

Class	Patient symptoms
Class 1 (Mild)	No limitation of physical activity. Ordinary physical activity does not cause undue fatigue, palpitation, dyspnoea (shortness of breath).
Class 2 (Mild)	Slight limitation of physical activity. Comfortable at rest. Ordinary physical activity results in fatigue, palpitation, dyspnoea (shortness of breath).
Class 3 (Moderate)	Marked limitation of physical activity. Comfortable at rest. Less than ordinary activity causes fatigue, palpitation, or dyspnoea.
Class 4 (Severe)	Unable to carry on any physical activity without discomfort. Symptoms of heart failure at rest. If any physical activity is undertaken, discomfort increases.

What causes heart failure?

Heart failure often occurs when a number of separate problems have been affecting the heart.

This can include:

Coronary heart disease
High blood pressure
Cardiomyopathy
Heart rhythm problems
Damage or other problems with the heart valves
Congenital heart disease

Sometimes anaemia, obesity, drinking too much alcohol, an overactive thyroid or high pressure in the lungs (pulmonary hypertension) can also lead to heart failure.²

Making the most of your time with your healthcare professional

Throughout the course of your treatment your healthcare team is your best resource for any information or advice. Speaking openly with them about your feelings or any questions you have can be a tremendous help.

Your specialist heart failure team (also known as a multidisciplinary team, or MDT) can work with your primary care team (e.g., your GP) and can include:

A doctor with training in heart failure (usually a consultant cardiologist)
A heart failure specialist nurse
A healthcare professional with expertise in dispensing medication for heart failure (e.g. a Pharmacist)

References

British Heart Foundation. Heart Failure. Available online at: https://www.bhf.org.uk/informationsupport/conditions/heart-failure#:~:text=Heart%20failure%20is%20a%20condition,%EF%BB%BF [Last accessed: June 2023]
NHS. Heart Failure Overview. Available online at: https://www.nhs.uk/conditions/heart-failure/ [Last accessed: May 2023]
Adapted from Dolgin M, Association NYH, Fox AC, Gorlin R, Levin RI, New York Heart Association. Criteria Committee. Nomenclature and criteria for diagnosis of diseases of the heart and great vessels. 9th ed. Boston, MA: Lippincott Williams and Wilkins; March 1, 1994.
Heart.org. Classes of Heart Failure. Available online at: https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure/classes-of-heart-failure [Last accessed: May 2023]

UK | May 2023 | 172743-2